Revillard J P
Laboratoire d'immunologie, INSERM U 80, hôpital Edourd-Herriot, Lyon.
Rev Prat. 1994 Jan 1;44(1):93-7.
The treatment of autoimmune diseases has long relied on corticosteroids and immunosuppressive drugs. Advances in the study of the mechanisms involved, and the development of new immunosuppressive agents used for transplantations have deeply modified the therapeutic approaches. These new treatments are evaluated on animal models, but their effectiveness can only be assessed by open, then controlled clinical trials. Cyclosporin A has been shown to be effective in several autoimmune diseases. Intravenous immunoglobulins, cytokines and anticytokines, immunotoxins, monoclonal anti-leucocyte antibodies (CD4, CD25, LFA-1) and soon peptide vaccination constitute new types of treatments which are now being evaluated.
自身免疫性疾病的治疗长期以来一直依赖于皮质类固醇和免疫抑制药物。相关作用机制研究的进展以及用于移植的新型免疫抑制剂的开发，已深刻改变了治疗方法。这些新疗法在动物模型上进行评估，但其有效性只能通过开放性试验，然后是对照临床试验来评估。环孢素A已被证明在几种自身免疫性疾病中有效。静脉注射免疫球蛋白、细胞因子和抗细胞因子、免疫毒素、单克隆抗白细胞抗体（CD4、CD25、LFA-1）以及不久后的肽疫苗接种构成了正在评估的新型治疗方法。
