Goţia S, Ionescu C
Clinica a II-a Pediatrie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 1995 Jan-Jun;99(1-2):35-42.
The various cell proportions that form the immune system intervene in the activation of autoreactive cells and in the occurrence of the associated inflammatory process. Advances of the study of the mechanism involved in the autoimmunity, and the development of new immunosuppressive agents used for transplantations have deeply modified the therapeutic approaches. The classic treatment of autoimmune diseases has relied on corticosteroids and immunosuppressive drugs. Now, these new treatments are evaluated on animal models, then controlled in clinical trials. Cyclosporin A has been shown to be effective in several autoimmune diseases. Intravenous immunoglobulins, cytokines, and anticytokines, immunotoxins, monoclonal anti-leukocyte antibodies (CD4, CD25) and soon peptide vaccination constitute the new types of treatments.
构成免疫系统的各种细胞比例参与自身反应性细胞的激活以及相关炎症过程的发生。自身免疫相关机制研究的进展以及用于移植的新型免疫抑制剂的开发深刻改变了治疗方法。自身免疫性疾病的传统治疗依赖于皮质类固醇和免疫抑制药物。现在，这些新疗法先在动物模型上进行评估，然后在临床试验中进行对照研究。环孢素A已被证明在几种自身免疫性疾病中有效。静脉注射免疫球蛋白、细胞因子和抗细胞因子、免疫毒素、单克隆抗白细胞抗体（CD4、CD25）以及不久之后的肽疫苗接种构成了新型治疗方法。
