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[聚对二氧环己酮增强髌腱移植替代前交叉韧带的组织学研究]

[Histologic studies of replacement of the anterior cruciate ligament with PDS-augmented patellar tendon transplants].

作者信息

Holzmüller W, Wehmeyer M, Rehm K E, Perren S M

机构信息

Unfall-, Hand- und Wiederherstellungschirurgie, Universität Köln.

出版信息

Unfallchirurg. 1994 Mar;97(3):144-50.

PMID:8178182
Abstract

The bone-patellar tendon-bone graft is currently the best substitute for the anterior cruciate ligament (ACL). To improve the results we compared a modified Jones procedure with an additional PDS augmentation. In 25 sheep the ACL was reconstructed in the left knee after total resection. The only resection of the ACL was done in all right knees. One year postoperative 21 sheep remained in the experiment and came to evaluation. There were 10 modified Jones procedures and 11 PDS augmentations. In both groups, the central one-third of the patellar tendon was implanted through a femoral and tibial drill hole for reconstruction of the anterior cruciate ligament. The transplants were fixed on both ends with a 1-mm cord of polydioxanon (PDS), a soft preload of 50 N was given with a spring balance and the ends of the cords were fixed with a screw and a washer. In the second group we did an additional augmentation with a doubled cord of 2 mm PDS. Early mobilization and weight-bearing was allowed. Throughout the observation period all animals were labelled for fluorescence microscopy. One year after resection of the ACL without reconstruction there were totally destroyed joints. Histology showed damaged menisci and joint surfaces without any cartilage as a sign of severe arthrosis. The macroscopic aspect of the transplants showed strong ligaments coated totally by a synovial membrane with good vascularization. Only little signs of degeneration were to be seen.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

髌腱-骨移植目前是前交叉韧带(ACL)的最佳替代物。为了提高手术效果,我们将改良的琼斯手术与额外的聚对二氧环己酮(PDS)增强术进行了比较。在25只绵羊中,左膝在完全切除ACL后进行重建。所有右膝仅切除ACL。术后一年,21只绵羊仍留在实验中并接受评估。其中10只采用改良琼斯手术,11只采用PDS增强术。两组均通过股骨和胫骨钻孔植入髌腱中三分之一来重建前交叉韧带。移植物两端用1毫米的聚对二氧环己酮(PDS)线固定,用弹簧秤施加50 N的软预负荷,线的两端用螺钉和垫圈固定。在第二组中,我们用双倍的2毫米PDS线进行了额外的增强。允许早期活动和负重。在整个观察期内,所有动物都进行了荧光显微镜标记。在未重建ACL切除术后一年,关节完全破坏。组织学显示半月板和关节面受损,没有任何软骨,这是严重关节炎的迹象。移植物的宏观外观显示,韧带强壮,完全被滑膜覆盖,血管化良好。仅可见轻微的退变迹象。(摘要截断于250字)

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