Meier-Hellmann A, Hannemann L, Reinhart K
Klinik für Anaesthesiologie und operative Intensivmedizin, Klinikum Steglitz der FU Berlin.
Zentralbl Chir. 1994;119(3):193-7.
The significance of the gastrointestinal region in the genesis and course of sepsis makes the monitoring of this region a fundamental importance in critical ill patients. The low-invasive assessment of gastric mucosal pH (pHi) seems to be able to detect a disturbed tissue oxygenation in the splanchnic region at an early stage. Animal studies have shown that there is a good correlation between pHi and directly measured pH. Splanchnic tissue hypoxia, induced in an experimental setting, is detectable by the pHi method. It has been shown in clinical studies that the patients' outcome depends on the first pHi, measured on admission to the ICU. An initial study has shown that patients with a pHi in the normal range on admission to the ICU had a better outcome if they were treated by a pHi-value orientated therapy. Nevertheless, some questions remain: There are problems with the practical use of this method, and it is unclear whether the pHi is really a marker for the whole splanchnic area. Further studies are required to determine the status of pHi in the clinical setting.
胃肠道区域在脓毒症的发生和发展过程中的重要性使得对该区域的监测成为危重症患者的一项至关重要的工作。对胃黏膜pH值（pHi）进行低侵入性评估似乎能够在早期检测到内脏区域组织氧合的紊乱。动物研究表明，pHi与直接测量的pH值之间存在良好的相关性。在实验环境中诱导的内脏组织缺氧可以通过pHi方法检测到。临床研究表明，患者的预后取决于入住重症监护病房（ICU）时首次测量的pHi。一项初步研究表明，入住ICU时pHi在正常范围内的患者，如果接受以pHi值为导向的治疗，其预后会更好。然而，仍然存在一些问题：该方法在实际应用中存在问题，并且尚不清楚pHi是否真的是整个内脏区域的标志物。需要进一步的研究来确定pHi在临床环境中的地位。
