Pimentel J, Nunes J F, Távora L, Trindade A, Ferreira A G
Laboratório de Neuropatologia (Serviço de Neurologia), Hospital de Santa Maria, Lisboa.
Acta Med Port. 1994 Feb;7(2):113-9.
Central neurocytomas are a well-characterized group of neuronal tumors usually arising in the supratentorial ventricular cavities. We describe the anatomical and clinical study of seven of these neoplasms. Patients were in the first four decades of life, and tumors were usually located in one of the lateral ventricles. Surgical resection was subtotal in 6 cases. Light microscopic examination revealed predominantly benign lesions with morphological features similar to the so-called ependymoma of the foramen of Monro, of the oligodendrogliomas, and of the neuroblastomas. Immunohistochemistry and electron microscopy confirmed the diagnosis in each case, showing expression of neuron specific enolase and synaptophysin and containing microtubuli, neurosecretory granules, and presynaptic vesicles. In agreement with the literature, the authors stress the benign behaviour of most of these tumors and the need for systematic immunohistochemical and ultrastructural study. The actual roles of the extent of resection and of postoperative radiotherapy are still a matter of discussion.
中枢神经细胞瘤是一组特征明确的神经元肿瘤，通常发生于幕上脑室腔。我们描述了其中7例肿瘤的解剖学和临床研究。患者年龄在人生的前4个十年，肿瘤通常位于一侧脑室。6例手术切除为次全切除。光镜检查显示主要为良性病变，形态学特征类似于所谓的孟氏孔室管膜瘤、少突胶质细胞瘤和神经母细胞瘤。免疫组化和电镜检查在每例中均确诊，显示神经元特异性烯醇化酶和突触素表达，含有微管、神经分泌颗粒和突触前囊泡。与文献一致，作者强调这些肿瘤大多数的良性行为以及进行系统免疫组化和超微结构研究的必要性。切除范围和术后放疗的实际作用仍存在争议。
