Prank K, Harms H, Dämmig M, Brabant G, Mitschke F, Hesch R D
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Germany.
Am J Physiol. 1994 Apr;266(4 Pt 1):E653-8. doi: 10.1152/ajpendo.1994.266.4.E653.
In many biological systems information is transferred by hormonal ligands, and it is assumed that these hormonal signals encode developmental and regulatory programs in mammalian organisms. The specificity of the biological response on activation by a hormone has so far been located within the interaction of a specific conformation of the ligand with the corresponding receptor structure. According to these classical explanations, the constant circulating hormonal pool described by the rate of its production and metabolic clearance is a major determinant of this interaction. Recently it has become apparent that hormone pulses contribute to this hormonal pool. Phase-space analysis of dynamic parathyroid hormone (PTH) secretion allowed the definition (in comparison to normal subjects) of a relatively quiet "low dynamic" secretory pattern in osteoporosis, and a "high dynamic" state in hyperparathyroidism. We now investigate whether this pulsatile secretion of PTH in healthy humans exhibits characteristics of low-dimensional deterministic chaos. Our findings suggest that this indeed appears to be the case. PTH secretion thus seems to be a first example of a chaotic hormonal rhythm in human physiology.
在许多生物系统中，信息是通过激素配体传递的，并且假定这些激素信号编码哺乳动物机体中的发育和调节程序。到目前为止，激素激活后生物反应的特异性一直被定位在配体的特定构象与相应受体结构的相互作用中。根据这些经典解释，由其产生速率和代谢清除率所描述的持续循环激素池是这种相互作用的主要决定因素。最近，激素脉冲对这个激素池的贡献已变得明显。动态甲状旁腺激素（PTH）分泌的相空间分析使得能够定义（与正常受试者相比）骨质疏松症中相对安静的“低动态”分泌模式以及甲状旁腺功能亢进中的“高动态”状态。我们现在研究健康人体内PTH的这种脉冲式分泌是否表现出低维确定性混沌的特征。我们的研究结果表明情况确实如此。因此，PTH分泌似乎是人类生理学中混沌激素节律的首个实例。
