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血浆激素浓度的时间序列预测。骨质疏松症患者与正常对照甲状旁腺激素分泌可预测性差异的证据。

Time series prediction of plasma hormone concentration. Evidence for differences in predictability of parathyroid hormone secretion between osteoporotic patients and normal controls.

作者信息

Prank K, Nowlan S J, Harms H M, Kloppstech M, Brabant G, Hesch R D, Sejnowski T J

机构信息

Howard Hughes Medical Institute, Salk Institute, San Diego, California 92186-5800, USA.

出版信息

J Clin Invest. 1995 Jun;95(6):2910-9. doi: 10.1172/JCI117998.

DOI:10.1172/JCI117998
PMID:7769133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC295979/
Abstract

Recent evidence links osteoporosis, a disease of bone remodeling, to changes in the dynamics of parathyroid hormone secretion. We use nonlinear and linear time series prediction to characterize the secretory dynamics of parathyroid hormone in both healthy human subjects and patients with osteoporosis. Osteoporotic patients appear to lack the periods of high predictability found in normal humans. Our results may provide an explanation for why an intermittent administration of parathyroid hormone is effective in restoring bone mass in osteoporotic patients.

摘要

近期证据表明，作为一种骨重塑疾病的骨质疏松症与甲状旁腺激素分泌动态变化有关。我们使用非线性和线性时间序列预测来表征健康人类受试者和骨质疏松症患者甲状旁腺激素的分泌动态。骨质疏松症患者似乎缺乏正常人中发现的高可预测性时期。我们的结果可能为间歇性给予甲状旁腺激素为何能有效恢复骨质疏松症患者骨量提供一种解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eda/295979/c8f9700981af/jcinvest00027-0495-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eda/295979/c8f9700981af/jcinvest00027-0495-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eda/295979/c8f9700981af/jcinvest00027-0495-a.jpg

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1
Time series prediction of plasma hormone concentration. Evidence for differences in predictability of parathyroid hormone secretion between osteoporotic patients and normal controls.血浆激素浓度的时间序列预测。骨质疏松症患者与正常对照甲状旁腺激素分泌可预测性差异的证据。
J Clin Invest. 1995 Jun;95(6):2910-9. doi: 10.1172/JCI117998.
2
[Osteoporosis at high remodeling and parathyroid function. Histo-biological confrontations (author's transl)].[高骨重塑与甲状旁腺功能状态下的骨质疏松症。组织生物学对比（作者译）]
Sem Hop. 1981;57(5-6):266-73.
3
[Osteoporosis at high remodeling and parathyroid function. Histo-biological confrontations (author's transl)].[高骨重建与甲状旁腺功能状态下的骨质疏松症。组织生物学对比研究（作者译）]
Pathol Biol (Paris). 1980 Sep;28(7):417-24.
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Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis.骨质疏松症女性甲状旁腺激素分泌及1,25 - 二羟维生素D3生成异常。
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Predicting PTH pulses and patterns in osteoporosis.预测骨质疏松症中的甲状旁腺激素脉冲和模式。
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Pulse amplitude and frequency modulation of parathyroid hormone in plasma.血浆中甲状旁腺激素的脉冲幅度和频率调制
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Reduced parathyroid hormone response to peroral phosphate in osteoporotic patients.骨质疏松症患者甲状旁腺激素对口服磷酸盐的反应降低。
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The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women.年龄对正常及骨质疏松女性血清免疫反应性甲状旁腺激素的影响。
J Lab Clin Med. 1980 Mar;95(3):373-85.

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Postmenopausal osteoporosis is associated with elevated aldosterone/renin ratio.绝经后骨质疏松症与醛固酮/肾素比值升高有关。
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Diurnal Rhythms of Bone Turnover Markers in Three Ethnic Groups.

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Effects of two treatment regimes with synthetic human parathyroid hormone fragment on bone formation and the tissue balance of trabecular bone in greyhounds.两种合成人甲状旁腺激素片段治疗方案对灵缇犬骨形成及小梁骨组织平衡的影响
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Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1-34) and 1,25-dihydroxyvitamin D.通过用人甲状旁腺激素（1-34）和1,25-二羟基维生素D治疗恢复骨质疏松男性的脊柱骨
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Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption.在甲状旁腺激素存在的情况下，成骨样细胞会释放刺激破骨细胞性骨吸收的可溶性因子。
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