Newman M A, Valanis B G, Schoeny R S, Hee S Q
Health Environments, Inc, Cincinnati, Ohio.
Am J Public Health. 1994 May;84(5):852-5. doi: 10.2105/ajph.84.5.852.
People handling anticancer drugs or their wastes may absorb these potent genotoxic agents. The aim of this study was to determine the utility of some general urinary markers among 24 female oncology nurses handling these drugs in comparison with 25 "unexposed" nurses. The markers were the Salmonella typhimurium reverse and forward mutation assays, total thioethers, and D-glucaric acid. The reverse mutation assay was the most specific and sensitive marker for anti-cancer drug exposure. Use of the marker battery was no great advantage as a screening tool relative to use of the reverse mutation assay alone. Better recording of work practices in nurse work logs would have improved interpretation of results.
接触抗癌药物或其废弃物的人员可能会吸收这些强效基因毒性剂。本研究的目的是确定24名接触这些药物的女性肿瘤护士与25名“未接触”护士相比，一些一般尿液标志物的效用。这些标志物包括鼠伤寒沙门氏菌反向和正向突变试验、总硫醚和D-葡糖二酸。反向突变试验是检测抗癌药物暴露最特异和敏感的标志物。相对于单独使用反向突变试验，使用这组标志物作为筛查工具并没有太大优势。护士工作记录中对工作实践的更好记录将有助于结果的解读。
