Monagle J, Wongprasartsuk P, Shearer W
Department of Anaesthesia, Dandenong Hospital, Victoria.
Aust N Z J Obstet Gynaecol. 1993 Nov;33(4):430-2. doi: 10.1111/j.1479-828x.1993.tb02131.x.
The effectiveness of fentanyl and ketorolac in providing analgesia for day-case gynaecological procedures was evaluated in 55 healthy volunteers in a single blinded fashion. Fentanyl (1 mcg/kg iv) and ketorolac (30 mg im) were administered immediately following induction of anaesthesia. Anaesthesia was standardized with propofol, nitrous oxide and enflurane. Outcome variables assessed were pain, additional analgesic requirements, and incidence of postoperative nausea and vomiting. All variables were recorded at 15 minutes, 2 hours and 24 hours postoperatively. There was no significant difference between the 2 groups with respect to any of the measured variables. Both drugs were ineffective as sole analgesic agents in half of their respective groups. It may be that a combination of these drugs, providing a multireceptor approach to analgesia, will prove to be more effective.
以单盲方式对55名健康志愿者评估了芬太尼和酮咯酸在日间妇科手术中提供镇痛的效果。麻醉诱导后立即静脉注射芬太尼（1微克/千克）和肌肉注射酮咯酸（30毫克）。用丙泊酚、氧化亚氮和恩氟烷使麻醉标准化。评估的结果变量为疼痛、额外镇痛需求以及术后恶心和呕吐的发生率。所有变量均在术后15分钟、2小时和24小时记录。两组在任何测量变量方面均无显著差异。两种药物在各自一半的组中作为单一镇痛剂均无效。或许将这些药物联合使用，采用多受体镇痛方法，会被证明更有效。
