Shapiro M H, Duffy B L
Department of Anaesthesia and Resuscitation, Queen Elizabeth Hospital, Adelaide, South Australia.
Anaesth Intensive Care. 1994 Feb;22(1):22-4. doi: 10.1177/0310057X9402200104.
The analgesic effect of intramuscular ketorolac was assessed by double blind study in forty women presenting for day-case laparoscopic sterilisation. The patients were randomly allocated to receive either ketorolac 30 mg or saline by intramuscular injection immediately following induction of general anaesthesia. There was no statistically significant difference between the groups in pain scores, opioid requirements or incidence of nausea and vomiting in the postoperative period. In view of the potential side-effects of ketorolac, and the apparent lack of efficacy when used prophylactically, the routine use of the drug in this group of patients cannot be recommended.
通过双盲研究评估了40名接受日间腹腔镜绝育术的女性肌肉注射酮咯酸的镇痛效果。患者在全身麻醉诱导后立即随机分配接受肌肉注射30毫克酮咯酸或生理盐水。两组在术后疼痛评分、阿片类药物需求量或恶心呕吐发生率方面无统计学显著差异。鉴于酮咯酸的潜在副作用以及预防性使用时明显缺乏疗效,不建议在这类患者中常规使用该药物。