腺嘌呤核苷酸能否预测人同种异体肝移植的原发性无功能？
Can adenine nucleotides predict primary nonfunction of the human liver homograft?
作者信息
Hamamoto I, Takaya S, Todo S, Bronsther O, Fujita S, Van Gulik T M, Nakamura K, Irish W, Starzl T E
机构信息
Pittsburgh Transplantation Institute, University of Pittsburgh School of Medicine, PA 15213.
出版信息
Transpl Int. 1994;7(2):89-95. doi: 10.1007/BF00336468.
Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction. AN, PC, and nicotinamide adenine dinucleotide, oxidized form (NAD+) of the tissue before (pretransplant) and after graft reperfusion (post-transplant) and of the effluent were analyzed. The graft outcome was classified into two groups (group A: successful, n = 64; group B: primary nonfunctioning, n = 4). No significant differences were observed in pretransplant measurements between groups A and B, whereas ATP, ADP, total AN, total AN + total PC (T) and NAD+, in post-transplant tissues, were significantly higher in group A. Xanthine in the effluent was significantly higher in group B than in group A. ATP, ADP, total AN, T, and NAD+ in post-transplant tissue were significantly associated with primary graft nonfunction by logistic regression analysis.
分析了68个原发性肝移植供肝，以观察组织或流出液中的腺嘌呤核苷酸（AN：三磷酸腺苷、二磷酸腺苷和一磷酸腺苷）或嘌呤分解代谢产物（PC：腺苷、肌苷、次黄嘌呤和黄嘌呤）是否能预测原发性移植肝无功能。分析了移植前和移植后再灌注时组织以及流出液中的AN、PC和氧化型烟酰胺腺嘌呤二核苷酸（NAD+）。移植结果分为两组（A组：成功，n = 64；B组：原发性无功能，n = 4）。A组和B组在移植前测量中未观察到显著差异，而移植后组织中的三磷酸腺苷、二磷酸腺苷、总AN、总AN + 总PC（T）和NAD+，A组显著更高。B组流出液中的黄嘌呤显著高于A组。通过逻辑回归分析，移植后组织中的三磷酸腺苷、二磷酸腺苷、总AN、T和NAD+与原发性移植肝无功能显著相关。
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