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肝脏缺血及随后的血液再灌注期间腺嘌呤核苷酸代谢及其与器官存活能力的关系。

Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability.

作者信息

Marubayashi S, Takenaka M, Dohi K, Ezaki H, Kawasaki T

出版信息

Transplantation. 1980 Oct;30(4):294-6. doi: 10.1097/00007890-198010000-00011.

DOI:10.1097/00007890-198010000-00011
PMID:7445052
Abstract

In an experimental model system for liver transplantation, the ability of the rat liver to synthesize ATP and to maintain adequate energy charge and total adenine nucleotides during restoration of hepatic blood flow following warm ischemia was found to determine tissue viability and survival of the animal. A portafemoral shunt prepared to relieve portal congestion enhanced the rate and extent of ATP resynthesis by the reflow following hepatic ischemia and this was accompanied by an increase in the survival rate of the rat.

摘要

在一个肝移植实验模型系统中,发现大鼠肝脏在热缺血后肝血流恢复过程中合成ATP以及维持充足能量电荷和总腺嘌呤核苷酸的能力决定了组织活力和动物的存活。为缓解门静脉充血而制备的门股分流术提高了肝缺血后再灌注时ATP再合成的速率和程度,并且这伴随着大鼠存活率的提高。

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Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability.肝脏缺血及随后的血液再灌注期间腺嘌呤核苷酸代谢及其与器官存活能力的关系。
Transplantation. 1980 Oct;30(4):294-6. doi: 10.1097/00007890-198010000-00011.
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