Cho K J, Ha C W, Koh J S, Zo J I, Jang J J
Department of Anatomic Pathology, Korea Cancer Center Hospital, Seoul.
J Korean Med Sci. 1993 Dec;8(6):458-63. doi: 10.3346/jkms.1993.8.6.458.
A carcinoid tumor of the thymus combined with thymoma in a 62-year-old man is described. The mediastinal tumor had been present for 13 years and was associated with pure red cell aplasia. Carcinoid tumor occupied the central two-thirds of the tumor, consisting of nests and trabeculae of monotonous round cells, which ultrastructurally showed many intracytoplasmic dense-core granules. Typical spindle cell type thymoma surrounded the carcinoid area. Clinico-pathologic findings of this unique case suggested that the carcinoid tumor developed within a preexisting thymoma, illustrating a possibility of neuroendocrine differentiation of thymic epithelial cells.
本文描述了一名62岁男性患者，其胸腺类癌合并胸腺瘤。纵隔肿瘤已存在13年，并伴有纯红细胞再生障碍。类癌占据肿瘤中央的三分之二，由形态单一的圆形细胞巢和小梁组成，超微结构显示许多胞质内致密核心颗粒。典型的梭形细胞型胸腺瘤环绕着类癌区域。该独特病例的临床病理表现提示，类癌是在先前存在的胸腺瘤内发生的，这表明胸腺上皮细胞存在神经内分泌分化的可能性。
