Kolnaar B G, van Lier A, van den Bosch W J, Folgering H, van Herwaarden C, van den Hoogen H J, van Weel C
Department of General Practice/Family Medicine, Nijmegen University, Netherlands.
Br J Gen Pract. 1994 Feb;44(379):73-8.
This study was undertaken to examine the relationship between respiratory illness in early childhood and asthma in adolescence and young adulthood (age group 10-23 years).
The study population comprised 277 boys and 274 girls, born between 1967 and 1978 and registered from their birth to the year of study (1989) on the practice lists of the four general practices taking part in the continuous morbidity registration project (CMR) at the University of Nijmegen in the Netherlands. Details of all episodes of respiratory morbidity presented in the first five years of life and registered in the project were collected together with data on current respiratory status determined by means of a questionnaire on respiratory symptoms, spirometry and a histamine-challenge test.
Sixteen per cent of the study group were diagnosed as having asthma. Only asthma and acute bronchitis in early childhood were significantly associated with asthma at age 10-23 years.
Asthma in adolescence and young adulthood is related to asthma and acute bronchitis in early childhood. This study supports the view that this could be a causal relationship although an alternative explanation could be misclassification. The results provide no indication that upper respiratory tract infections are associated with the development of asthma in adolescence or young adulthood.
本研究旨在探讨儿童早期呼吸道疾病与青少年及青年期（10 - 23岁年龄组）哮喘之间的关系。
研究人群包括277名男孩和274名女孩，他们于1967年至1978年出生，并从出生至研究年份（1989年）在参与荷兰奈梅亨大学持续性发病率登记项目（CMR）的四家全科诊所的执业名单上进行了登记。收集了项目中登记的生命最初五年内所有呼吸道发病情况的详细信息，以及通过呼吸道症状问卷、肺活量测定和组胺激发试验确定的当前呼吸道状况数据。
研究组中有16%被诊断患有哮喘。只有儿童早期的哮喘和急性支气管炎与10 - 23岁时的哮喘显著相关。
青少年及青年期的哮喘与儿童早期的哮喘和急性支气管炎有关。本研究支持这可能是一种因果关系的观点，尽管另一种解释可能是错误分类。结果未表明上呼吸道感染与青少年或青年期哮喘的发生有关。
