Murphy N M, Olney D B, Brakenbury P H
Accident and Emergency Department, Milton Keynes General Hospital.
Br J Clin Pract. 1994 Jan-Feb;48(1):8-9.
Patients who are not known to be immunised to tetanus are considered to be non-immune. The appropriate treatment is the commencement of active immunisation with a course of three tetanus toxoid inoculations; if the wound is considered to be tetanus-prone, 250 IU of human anti-tetanus immunoglobulin is given concurrently. This study determined the true immune status of 166 patients who were considered to be non-immune on the basis of the available history. The majority (90 of 166) had protective levels of immunoglobulin (greater than 0.06 IU/ml) and further treatment was not indicated. Only two patients were non-immune. The remainder had protective levels (between 0.01 and 0.06 IU/ml) and required a tetanus toxoid booster.
已知未接种破伤风疫苗的患者被视为无免疫力。适当的治疗方法是开始进行主动免疫，接种三针破伤风类毒素；如果伤口被认为有破伤风感染风险，则同时给予250国际单位的人抗破伤风免疫球蛋白。本研究确定了166例根据现有病史被认为无免疫力的患者的真实免疫状态。大多数患者（166例中的90例）免疫球蛋白水平具有保护性（大于0.06国际单位/毫升），无需进一步治疗。只有两名患者无免疫力。其余患者免疫球蛋白水平具有保护性（在0.01至0.06国际单位/毫升之间），需要接种破伤风类毒素加强针。
