Kurjak A, Predanic M
Ultrasonic Institute, Medical School, University of Zagreb, Croatia.
Curr Opin Obstet Gynecol. 1994 Feb;6(1):67-74.
To reduce the mortality from ovarian cancer various studies by transvaginal color Doppler (TVCD) sonography and serum CA-125 tumor marker, alone or in combination, have been performed. Relatively poor specificities of CA-125 and transvaginal conventional sonography can be improved with the use of TVCD. Furthermore, high specificity can be achieved on screening asymptomatic postmenopausal women by combining serum CA-125 measurement with TVCD. Combining tests should not necessarily increase the overall cost of screening because of the expected decrease in the number of unnecessary surgical interventions. Until the results of large, prospective studies are available, the efficacy of potential tests for screening of ovarian cancer will remain unproven and they should not be used to screen apparently healthy women outside of scientific interest.
为降低卵巢癌死亡率，已开展了多项经阴道彩色多普勒（TVCD）超声检查和血清CA - 125肿瘤标志物单独或联合应用的研究。使用TVCD可提高CA - 125和经阴道传统超声检查相对较差的特异性。此外，通过将血清CA - 125检测与TVCD相结合，在筛查无症状绝经后女性时可实现高特异性。由于预期不必要的手术干预数量会减少，联合检测不一定会增加筛查的总体成本。在获得大型前瞻性研究结果之前，卵巢癌潜在筛查检测的有效性仍未得到证实，除了出于科学研究兴趣外，不应将其用于筛查表面健康的女性。
