Schapira M M, Matchar D B, Young M J
Medical College of Wisconsin, Milwaukee.
Ann Intern Med. 1993 Jun 1;118(11):838-43. doi: 10.7326/0003-4819-118-11-199306010-00002.
To estimate the effectiveness of ovarian cancer screening with CA 125 and transvaginal sonography.
Decision analysis was used to examine the no-screen compared with the screen strategy.
Estimates of cancer incidence, survival, and life expectancy were derived from population-based data and clinical series.
A cohort of 40-year-old women of all races and residing in the United States.
A one-time screening intervention. The criterion standard for diagnosis of ovarian cancer was evaluation with exploratory laparotomy.
Average years of life expectancy gained by women in the screened group.
Screening for ovarian cancer with a combination of CA 125 and transvaginal sonography increases the average life expectancy in the population by less than 1 day.
Given the limited effect on overall life expectancy, it is unlikely that mass screening for ovarian cancer with CA 125 and transvaginal sonography would be an effective health policy.
评估采用CA 125和经阴道超声进行卵巢癌筛查的有效性。
采用决策分析来检验不筛查策略与筛查策略。
癌症发病率、生存率和预期寿命的估计值来自基于人群的数据和临床系列研究。
居住在美国的所有种族40岁女性队列。
一次性筛查干预。卵巢癌诊断的标准方法是进行剖腹探查术评估。
筛查组女性获得的平均预期寿命年数。
联合使用CA 125和经阴道超声进行卵巢癌筛查，使人群的平均预期寿命增加不到1天。
鉴于对总体预期寿命的影响有限，采用CA 125和经阴道超声进行卵巢癌大规模筛查不太可能成为一项有效的卫生政策。
