Lemmer B, Brühl T, Witte K, Pflug B, Köhler W, Touitou Y
Centre of Pharmacology, JW Goethe University, Frankfurt/Main, Germany.
Eur J Endocrinol. 1994 May;130(5):472-7. doi: 10.1530/eje.0.1300472.
Bright light is known as a strong zeitgeber on human circadian rhythms and influences several endocrine and neuroendocrine functions. In the present study we examined the influence of a 3-h bright light stimulus, given at different times during the day (morning or evening), on circadian patterns of cyclic adenosine monophosphate (cAMP), melatonin and cortisol. Two groups of synchronized healthy volunteers (lights on: 05.00-23.00 h) were exposed to bright light (2500 lux) for 3 h over 6 days either in the morning (05.00-08.00 h) or in the evening (18.00-21.00 h). The results showed a significant phase advance in the circadian rhythms of melatonin and cortisol when bright light was given in the morning but not when given in the evening. Rhythm in plasma cAMP basically was not affected by either light treatment.
强光被认为是影响人类昼夜节律的强大授时因子，并且会影响多种内分泌和神经内分泌功能。在本研究中，我们检测了在一天中的不同时间（早晨或晚上）给予3小时强光刺激对环磷酸腺苷（cAMP）、褪黑素和皮质醇昼夜节律模式的影响。两组同步的健康志愿者（开灯时间：05:00 - 23:00）在6天内的早晨（05:00 - 08:00）或晚上（18:00 - 21:00）接受3小时的强光（2500勒克斯）照射。结果显示，早晨给予强光时，褪黑素和皮质醇的昼夜节律出现显著的相位提前，而晚上给予强光时则没有。血浆cAMP的节律基本上不受任何一种光照处理的影响。
