Kennaway D J, Earl C R, Shaw P F, Royles P, Carbone F, Webb H
J Pineal Res. 1987;4(3):315-20. doi: 10.1111/j.1600-079x.1987.tb00869.x.
The purpose of this study was to investigate the effect of bright artificial light exposure on the rhythms of 6-sulphatoxy melatonin and cortisol excretion in urine. Six healthy males were exposed to light (greater than 3,000 lux) from 1900 to 0200 h (sunset 1928 h) on one occasion. The artificial light delayed the onset of 6-sulphatoxy melatonin excretion. On the next evening the onset of 6-sulphatoxy melatonin excretion in normal light/darkness was delayed by 1 h. The timing of the peak excretion of cortisol was not affected by the light treatment; however, cortisol excretion rate was maintained at a significantly higher rate in the morning and afternoon after the treatment. These results demonstrate the inhibitory action of high intensity light in humans and suggest that one 6-h period of extra light in the evening can phase delay the melatonin onset.
本研究的目的是调查暴露于明亮人工光对尿液中6-硫酸氧褪黑素和皮质醇排泄节律的影响。6名健康男性曾在某一时刻于19:00至02:00（日落时间为19:28）暴露于光照（大于3000勒克斯）下。人工光延迟了6-硫酸氧褪黑素排泄的开始时间。在接下来的晚上，正常明暗条件下6-硫酸氧褪黑素排泄的开始时间延迟了1小时。皮质醇排泄峰值的时间不受光照处理的影响；然而，处理后的上午和下午，皮质醇排泄率维持在显著更高的水平。这些结果证明了高强度光对人体的抑制作用，并表明晚上额外1个6小时的光照期可使褪黑素开始时间发生相位延迟。
