Touitou Y, Benoit O, Foret J, Aguirre A, Bogdan A, Clodoré M, Touitou C
Biochemical Department, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Acta Endocrinol (Copenh). 1992 Mar;126(3):201-5. doi: 10.1530/acta.0.1260201.
Bright light is a synchronizing agent that entrains human circadian rhythms and modifies various endocrine and neuroendocrine functions. The aim of the present study was to determine whether and how the exposure to a bright light stimulus during the 2 h following a 2 h earlier awakening could modify the disturbance induced by the the sleep deprivation on the plasma patterns of hormones whose secretion is sensitive to light and/or sleep, namely melatonin, prolactin, cortisol and testosterone. Six healthy and synchronized (lights on: 07.00-23.00) male students (22.5 +/- 1.1 years) with normal psychological profiles volunteered for the study in winter. The protocol consisted of a baseline control night (customary sleep schedule) followed by three shortened nights with a rising at 05.00 and a 2 h exposure to either dim light (50 lux; one week) or bright light (2000 lux; other week). Our study showed a phase advance of the circadian rhythm of plasma cortisol without significant modifications of the hormone mean or peak concentration. Plasma melatonin concentration decreased following bright light exposure, whereas no obvious modifications of plasma testosterone or prolactin patterns could be observed in this protocol.
强光作为一种同步因子，可调节人体昼夜节律，并改变各种内分泌和神经内分泌功能。本研究旨在确定在提前两小时醒来后的两小时内暴露于强光刺激下，是否以及如何改变睡眠剥夺对血浆中对光和/或睡眠敏感的激素模式的干扰，这些激素包括褪黑素、催乳素、皮质醇和睾酮。六名心理状况正常、健康且睡眠同步（开灯时间：07:00 - 23:00）的男性学生（22.5 ± 1.1岁）在冬季自愿参与了这项研究。实验方案包括一个基线对照夜（常规睡眠时间表），随后是三个缩短的夜晚，在05:00起床，并在接下来的两小时内暴露于弱光（50勒克斯；一周）或强光（2000勒克斯；另一周）下。我们的研究表明，血浆皮质醇的昼夜节律出现了相位提前，但激素的平均浓度或峰值浓度没有显著变化。强光暴露后血浆褪黑素浓度降低，但在该实验方案中未观察到血浆睾酮或催乳素模式有明显变化。
