Battaglia S, Casali A M, Botticelli A R
Istituto di Anatomia e Istologia Patologica, Genova, Italy.
Virchows Arch. 1994;424(2):165-8. doi: 10.1007/BF00193496.
A morphometric analysis was performed to obtain quantitative data on age-related changes in prostatic endocrine cell (PrEC) density. Sixty prostates from subjects aged 14-74 years were studied with a semi-automatic image analysis system (ASM 68K, Leitz) applied to sections immunostained for chromogranin A-reactive cells. The highest density of PrECs (0.366 cells/mm of epithelial length) was found in the 25-54 year age group, which was significantly different from that found in prostates of the younger (0.311 cells/mm) and the older (0.261 cells/mm) age groups. The data probably reflect the higher incidence of incompletely developed glandular units in the younger group and the formation of new alveoli related to the usual glandular hyperplasia that occurs with increasing age in the older group.
进行了形态计量分析，以获取有关前列腺内分泌细胞（PrEC）密度随年龄变化的定量数据。使用半自动图像分析系统（ASM 68K，徕卡）对60个年龄在14至74岁之间的前列腺进行研究，该系统应用于对嗜铬粒蛋白A反应性细胞进行免疫染色的切片。PrEC的最高密度（0.366个细胞/上皮长度毫米）出现在25至54岁年龄组，这与较年轻年龄组（0.311个细胞/毫米）和较年长年龄组（0.261个细胞/毫米）的前列腺中发现的密度有显著差异。这些数据可能反映了较年轻组中未完全发育的腺单位发生率较高，以及与较年长组中随着年龄增长而发生的常见腺体增生相关的新肺泡形成。
