Shaw P A
Department of Histopathology, Leicester Royal Infirmary, U.K.
J Pathol. 1991 Jul;164(3):235-9. doi: 10.1002/path.1711640308.
In order to clarify the histogenesis of appendiceal carcinoid tumours, epithelial (ENC) and subepithelial (SNC) neuroendocrine cells were counted at four sites in 50 normal appendices stained by standard argyrophil and argentaffin techniques. In general, ENC were present in similar number at all sites within the appendix, whereas SNC were more numerous at the tip than at the base. The number of ENC was similar throughout life, apart from an increase in one neonate and some elderly patients, whereas SNC were maximal in young adults. Thus, the topographical and age distributions of SNC, but not those of ENC, parallels the topographical and age incidence of appendiceal carcinoid tumours, suggesting that most appendiceal carcinoid tumours arise from SNC rather than ENC.
为了阐明阑尾类癌肿瘤的组织发生，采用标准嗜银和亲银技术对50例正常阑尾的四个部位的上皮（ENC）和上皮下（SNC）神经内分泌细胞进行计数。一般来说，ENC在阑尾内所有部位的数量相似，而SNC在尖端比在基部更多。除了一名新生儿和一些老年患者数量增加外，ENC的数量在一生中相似，而SNC在年轻成年人中最多。因此，SNC的地形和年龄分布，而非ENC的，与阑尾类癌肿瘤的地形和年龄发病率平行，表明大多数阑尾类癌肿瘤起源于SNC而非ENC。
