Ohuoha D C, Knable M B, Wolf S S, Kleinman J E, Hyde T M
Clinical Brain Disorders Branch, NIMH, St. Elizabeths Hospital, Washington, DC 20032.
Brain Res. 1994 Feb 21;637(1-2):222-6. doi: 10.1016/0006-8993(94)91236-x.
The distribution of 5-HT3 receptors was examined in the human medulla using [3H]LY278584, a highly selective 5-HT3 receptor antagonist. The highest density of 5-HT3 receptors was found in the substantia gelatinosus subnucleus of nucleus of the solitary tract (NTS) throughout its rostrocaudal extent, followed by the dorsal subnucleus, the area postrema (AP), the commissural subnucleus, the medial subnucleus, and in an arc corresponding to the pars gelatinosus of the spinal trigeminal nucleus (nSp5). The distribution of 5-HT3 receptors in the brain may help explain some of the reported CNS activities of 5-HT3-selective drugs. The anti-emetic and antinociceptive activities of 5-HT3 antagonists may be mediated by receptors in sensory areas of the brainstem.
使用高选择性5-HT3受体拮抗剂[3H]LY278584研究了5-HT3受体在人延髓中的分布。在孤束核（NTS）的胶状质亚核中，沿其前后范围发现5-HT3受体密度最高，其次是背侧亚核、最后区（AP）、连合亚核、内侧亚核，以及与三叉神经脊束核（nSp5）胶状质部分相对应的弧形区域。5-HT3受体在脑中的分布可能有助于解释一些已报道的5-HT3选择性药物的中枢神经系统活性。5-HT3拮抗剂的止吐和抗伤害感受活性可能由脑干感觉区域的受体介导。
