Lu X C, Slotnick B M
Department of Psychology, American University, Washington, DC 20016.
Brain Res. 1994 Mar 7;639(1):26-32. doi: 10.1016/0006-8993(94)91760-4.
Rats were trained in an olfactometer to recognize the odor of propionic acid using a go, no-go operant discrimination tasks in which propionic acid vapor served as the negative stimulus and a series of novel odors served as positive stimuli. After training, rats readily responded to all novel odors but not to propionic acid. Removal of the olfactory bulb region previously identified with 2-deoxyglucose (2-DG) as being responsive to propionic acid had no effect on recognition of propionic acid, ability to discriminate novel odors from propionic acid or odor mixtures containing propionic acid or to discriminate propionic acid from a very similar odor (acetic acid). These results demonstrate that the 2-DG-identified propionic acid focal area is not essential for detection, discrimination or recognition of the odor. The outcomes are in accord with and extend those of other behavioral studies that have failed to demonstrate a functional correlate for the regional increases in metabolic activity produced by exposure to specific odors.
在嗅觉计中训练大鼠，通过“是-否”操作性辨别任务来识别丙酸气味，其中丙酸蒸汽作为负性刺激，一系列新气味作为正性刺激。训练后，大鼠对所有新气味都有反应，但对丙酸没有反应。去除先前用2-脱氧葡萄糖（2-DG）鉴定为对丙酸有反应的嗅球区域，对丙酸的识别、区分新气味与丙酸或含丙酸的气味混合物的能力，或区分丙酸与非常相似的气味（乙酸）的能力均无影响。这些结果表明，2-DG鉴定的丙酸焦点区域对于气味的检测、辨别或识别并非必不可少。这些结果与其他行为学研究一致并有所扩展，那些研究未能证明接触特定气味所产生的代谢活动区域增加存在功能相关性。
