Slotnick B M, Bell G A, Panhuber H, Laing D G
Department of Psychology, The American University, Washington, DC 20016, USA.
Brain Res. 1997 Jul 11;762(1-2):89-96. doi: 10.1016/s0006-8993(97)00357-0.
Prior 2-deoxyglucose and c-fos studies have demonstrated increased metabolic activity in a rostral dorsomedial area of the olfactory bulb in response to the vapor of propionic acid. We used psychophysical tests to assess the effect of removing this area of the bulb on odor sensitivity and discrimination. Normal rats, those with lesions of the rostral dorsomedial bulb or with control lesions of the lateral olfactory bulb were tested for propionic acid absolute detection and intensity difference thresholds and ability to discriminate propionic acid from other odors. There were no differences among groups for absolute or intensity difference threshold or on simple 2-odor discrimination tests but both groups with bulbar lesions made more errors than controls on a relatively difficult odor-mixture task. The results demonstrate that removal of an area of the bulb identified as responsive to propionic acid is essentially without effect on sensitivity to that odor or ability to discriminate it from other odors.
先前的2-脱氧葡萄糖和c-fos研究表明，嗅球嘴侧背内侧区域的代谢活动会因丙酸蒸汽而增强。我们通过心理物理学测试来评估切除嗅球该区域对气味敏感度和辨别能力的影响。对正常大鼠、嘴侧背内侧嗅球损伤的大鼠或外侧嗅球对照损伤的大鼠进行了丙酸绝对检测、强度差异阈值以及区分丙酸与其他气味能力的测试。在绝对阈值或强度差异阈值方面，以及在简单的双气味辨别测试中，各组之间没有差异，但在一项相对困难的气味混合任务中，两组嗅球损伤的大鼠比对照组犯的错误更多。结果表明，切除被确定对丙酸有反应的嗅球区域，对该气味的敏感度或与其他气味的辨别能力基本上没有影响。
