底物附着的小鼠骨髓瘤细胞合成免疫球蛋白。
Synthesis of immunoglobulin by substrate attached mouse myeloma cells.
作者信息
Bargellesi A, Damiani G, Kuehl W M, Scharff M D
出版信息
J Cell Physiol. 1976 Jun;88(2):247-51. doi: 10.1002/jcp.1040880214.
PMID:818094
Abstract
Cultured mouse myeloma cells grow in suspension and synthesize and secrete large amounts of immunoglobulin. Mouse myeloma cells which attach to a plastic substratum have been obtained by mutagenesis and subsequent selection. Normal mouse myeloma cells will also attach to plastic tissue culture dishes pre-treated with poly-L-lysine. The attached cells synthesize and secrete the same large amounts of immunoglobulin as the suspended cells.
摘要
培养的小鼠骨髓瘤细胞在悬浮状态下生长，并合成和分泌大量免疫球蛋白。通过诱变和后续筛选已获得附着于塑料基质的小鼠骨髓瘤细胞。正常的小鼠骨髓瘤细胞也会附着于用聚-L-赖氨酸预处理过的塑料组织培养皿上。附着的细胞与悬浮细胞合成和分泌相同大量的免疫球蛋白。
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