Jiang Y, Möller G
Department of Immunology, Stockholm University, Sweden.
Cell Immunol. 1994 May;155(2):394-401. doi: 10.1006/cimm.1994.1132.
Lipopolysaccharide (LPS)-activated B lymphocytes have been found to produce autoantibodies of a variety of specificities. We found that LPS-induced autoantibodies did not include antibodies against self H-2 class I antigens, suggesting a selective tolerance induction against some, but not other, autoantigens. However, LPS-activated B lymphocytes not only failed to produce antibodies against autologous H-2 class I antigens, but also against allogeneic H-2 class I antigens, suggesting a selective regulation of B cells to synthesize antibodies directed against autologous and allogeneic major histocompatibility complex antigens.
已发现脂多糖（LPS）激活的B淋巴细胞可产生多种特异性的自身抗体。我们发现，LPS诱导产生的自身抗体不包括针对自身H-2 I类抗原的抗体，这表明对某些自身抗原而非其他自身抗原存在选择性耐受诱导。然而，LPS激活的B淋巴细胞不仅未能产生针对自体H-2 I类抗原的抗体，也未能产生针对同种异体H-2 I类抗原的抗体，这表明对B细胞存在选择性调节，使其合成针对自体和同种异体主要组织相容性复合体抗原的抗体。
