Effects of iron and deferoxamine on cisplatin-induced emesis: further evidence for the role of free radicals.
作者信息
Matsuki N, Torii Y, Saito H
机构信息
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Eur J Pharmacol. 1993 Dec 1;248(4):329-31. doi: 10.1016/0926-6917(93)90008-e.
PMID:8181539
Abstract
The effects of ferric chloride and deferoxamine, an iron chelator, on cisplatin-induced emesis were studied in Suncus murinus. Pretreatment with ferric chloride (FeCl3, 16-64 mg/kg) increased the number of 20 mg/kg cisplatin-induced vomiting episodes. Deferoxamine (256 mg/kg) significantly reduced the number of vomiting episodes and prolonged the latency. These results further support the involvement of free radicals in the generation of cisplatin-induced emesis.
摘要
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