Salazar Esquivel E L, Paredes López A, Calzada Sánchez L
Unidad de Investigación Médica en Biología de la Reproducción, Hospital de Gineco-Obstetricia Luis Castelazo Ayala IMSS, México, D.F.
Ginecol Obstet Mex. 1994 Feb;62:48-51.
The concentration of receptor to estradiol (E-R) progesterone (Pg-R) and dexamethasone (G-R) was studied, by the dextran coated charcoal method in the cytosol of the mammary gland tissue from patients with infiltrating ductal carcinoma. The study was done in one hundred cases. 45% of these patients were postmenopausic and 55% premenopausic, with average ages of 66 and 37 years respectively. Their first pregnancy occurred on average at 24 years and they had 3-4 gestations, 45% breast-fed for a minimum period of six months and menarche at 13 years. The specific union found in the tumours was considered "receptor positive" were in the range of 10 to 181 femtomoles/mg. The "Receptor negative" tumour was considered to have a specific union less than 10 femtomoles/mg protein. On using E-R as a marker to predict the hormonal treatment it was found in this study that 56% of these patients demonstrated R-E+ and was absent in 44%. Simultaneous determination of E-R and Pg-R, raised the number of patients presenting specific receptors to 70% and on determining E-R, Pg-R and G-R, in the same tumours as markers of hormone dependence, the number of patients that presented them, increased to 77%. Finally 23% of these patients did not contain E-R, Pg-R or G-R. When the values of R-E+ were grouped according to the menstrual state of the patient, it was found that the high values of R-E+ corresponded to the postmenopausic patients. No relation was found between the concentration of R-Pg+ and R-G+ and the patient's menstrual state.
采用葡聚糖包被活性炭法，对浸润性导管癌患者乳腺组织胞浆中雌二醇受体（E-R）、孕酮受体（Pg-R）和地塞米松受体（G-R）的浓度进行了研究。该研究共纳入100例患者。其中45%为绝经后患者，55%为绝经前患者，平均年龄分别为66岁和37岁。她们首次怀孕的平均年龄为24岁，平均妊娠3 - 4次，45%的患者至少母乳喂养6个月，初潮年龄为13岁。肿瘤中发现的特异性结合量在10至181飞摩尔/毫克之间被认为是“受体阳性”。“受体阴性”肿瘤的特异性结合量被认为低于10飞摩尔/毫克蛋白质。在本研究中，以E-R作为预测激素治疗的标志物时，发现56%的患者E-R呈阳性，44%的患者E-R阴性。同时测定E-R和Pg-R，使呈现特异性受体的患者数量增加到70%，而在同一肿瘤中同时测定E-R、Pg-R和G-R作为激素依赖性标志物时，呈现这些受体的患者数量增加到77%。最后，23%的患者不含E-R、Pg-R或G-R。当根据患者的月经状态对E-R阳性值进行分组时，发现E-R阳性的高值与绝经后患者相对应。未发现Pg-R阳性和G-R阳性的浓度与患者的月经状态之间存在关联。
