Carneiro F, Santos L, David L, Dabelsteen E, Clausen H, Sobrinho-Simões M
Department of Pathology, IPATiMvP, Medical School, University of Porto, Portugal.
Histopathology. 1994 Feb;24(2):105-13. doi: 10.1111/j.1365-2559.1994.tb01288.x.
In a previous report we suggested that T antigen appeared to be associated with gastric carcinoma. To verify this hypothesis and characterize the pattern of expression of simple-mucin type carbohydrate antigens (Tn,sialyl-Tn and T before and after neuraminidase) in normal gastric mucosa and precursor lesions of gastric carcinoma, we studied the mucosa adjacent to 100 cases of gastric carcinoma, gastric biopsies of 60 dyspeptic patients, eight adenomatous polyps and eight hyperplastic polyps. The expression of the antigens was more related to the cell type and underlying lesions than to the coexistence of carcinoma. The most distinctive findings concerned intestinal metaplasia, dysplasia and hyperplastic lesions. In intestinal metaplasia, Tn was found mostly in columnar cells and sialyl-Tn in goblet cells. T was more prevalent in incomplete intestinal metaplasia than in complete. A high prevalence of sialyl-Tn expression and cell membrane immunoreactivity for T antigen, similar to those previously found in gastric carcinomas, were observed in three adenomatous polyps, one hyperplastic polyp, five cases of adenomatous dysplasia in the neighbourhood of intestinal carcinomas and four cases of marked foveolar hyperplasia, three of which were from the mucosa adjacent to diffuse carcinomas. We conclude that adenomatous and hyperplastic lesions share with gastric carcinomas features of aberrant glycosylation, namely the cell membrane expression of T antigen.
在之前的一份报告中，我们提出T抗原似乎与胃癌相关。为了验证这一假设，并描述正常胃黏膜及胃癌前病变中简单粘蛋白型碳水化合物抗原（Tn、唾液酸化Tn以及神经氨酸酶处理前后的T抗原）的表达模式，我们研究了100例胃癌旁黏膜、60例消化不良患者的胃活检组织、8个腺瘤性息肉以及8个增生性息肉。抗原的表达与细胞类型和潜在病变的关系比与癌的并存关系更为密切。最显著的发现涉及肠化生、发育异常和增生性病变。在肠化生中，Tn主要见于柱状细胞，唾液酸化Tn见于杯状细胞。T抗原在不完全肠化生中比在完全肠化生中更普遍。在3个腺瘤性息肉、1个增生性息肉、肠型癌附近的5例腺瘤性发育异常以及4例明显的胃小凹增生中，观察到唾液酸化Tn表达和T抗原细胞膜免疫反应性的高发生率，其中3例来自弥漫性癌旁黏膜。我们得出结论，腺瘤性和增生性病变与胃癌具有异常糖基化特征，即T抗原的细胞膜表达。
