克拉霉素与磺胺甲恶唑联合治疗实验性卡氏肺孢子虫感染
Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole.
作者信息
Alder J, Mitten M, Shipkowitz N, Hernandez L, Hui Y H, Marsh K, Clement J
机构信息
Anti-Infective Research Division, Abbott Laboratories, Illinois.
出版信息
J Antimicrob Chemother. 1994 Feb;33(2):253-63. doi: 10.1093/jac/33.2.253.
The efficacy of clarithomycin and sulphamethoxazole for treatment of experimental Pneumocystis carinii infection was investigated. Rats were immunosuppressed with dexamethasone and inoculated intratracheally with 5 x 10(6) P. carinii cysts. After 2 weeks, the lung tissues were assayed for P. carinii cyst burden. The combination of clarithromycin and sulphamethoxazole caused a significantly greater reduction in cyst burden than either drug alone. Up to 50% of the rats treated with the combination of clarithromycin and sulphamethoxazole were negative for P. carinii cysts. Equivalent doses of the individual drugs given alone did not produce cures. The combination of clarithromycin and sulphamethoxazole was more than twice as effective as either drug alone. Clarithromycin combined with sulphamethoxazole in treatment of P. carinii infection could be especially useful since clarithromycin monotherapy provides safe and effective treatment against many other pathogens, including several that are associated with AIDS.
研究了克拉霉素和磺胺甲恶唑治疗实验性卡氏肺孢子虫感染的疗效。用 dexamethasone 对大鼠进行免疫抑制，经气管内接种 5×10(6)个卡氏肺孢子虫包囊。2 周后，检测肺组织中的卡氏肺孢子虫包囊负荷。克拉霉素和磺胺甲恶唑联合使用导致的包囊负荷降低幅度明显大于单独使用任何一种药物。接受克拉霉素和磺胺甲恶唑联合治疗的大鼠中，高达 50%的大鼠卡氏肺孢子虫包囊呈阴性。单独给予等效剂量的各药物均未治愈。克拉霉素和磺胺甲恶唑联合使用的效果是单独使用任何一种药物的两倍多。克拉霉素与磺胺甲恶唑联合治疗卡氏肺孢子虫感染可能特别有用，因为克拉霉素单一疗法可为对抗许多其他病原体提供安全有效的治疗，包括几种与艾滋病相关的病原体。
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