亚叶酸对甲氧苄啶-磺胺甲恶唑预防和治疗大鼠卡氏肺孢子虫肺炎能力的影响。
Effect of folinic acid on the capacity of trimethoprim-sulfamethoxazole to prevent and treat Pneumocystis carinii pneumonia in rats.
作者信息
D'Antonio R G, Johnson D B, Winn R E, van Dellen A F, Evans M E
出版信息
Antimicrob Agents Chemother. 1986 Feb;29(2):327-9. doi: 10.1128/AAC.29.2.327.
Abstract
Daily administration of 1 mg of folinic acid to immunosuppressed rats with incipient or established Pneumocystis carinii pneumonia did not impair the capacity of trimethoprim-sulfamethoxazole to either prevent or treat this disease. These observations constitute the first experimental support for the use of folinic acid to prevent or control cytopenias that occur in patients with Pneumocystis carinii pneumonia who are under trimethoprim-sulfamethoxazole treatment.
摘要
对患有初期或已确诊卡氏肺孢子虫肺炎的免疫抑制大鼠每日给予1毫克亚叶酸，并不影响甲氧苄啶-磺胺甲恶唑预防或治疗该病的能力。这些观察结果为使用亚叶酸预防或控制接受甲氧苄啶-磺胺甲恶唑治疗的卡氏肺孢子虫肺炎患者出现的血细胞减少症提供了首个实验依据。
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