Armstrong J W, Simske S J, Beharka A A, Balch S, Luttges M W, Chapes S K
Division of Biology, Kansas State University, Manhattan 66506-4901.
J Leukoc Biol. 1994 May;55(5):658-61. doi: 10.1002/jlb.55.5.658.
Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development.
I类和II类主要组织相容性复合体（MHC）分子在T细胞发育和免疫功能中发挥着重要作用。我们发现，缺乏MHCI和MHCII的小鼠巨噬细胞前体和循环单核细胞数量较少，同时伴有异常的骨髓细胞集落刺激因子1分泌和骨骼组成。我们认为，MHCI和MHCII分子在巨噬细胞发育中发挥着重要作用。
