Gupta A K, Shashi S, Lamba I M, Anand N K
Department of Pediatrics, Safdarjang Hospital, New Delhi, India.
J Trop Pediatr. 1994 Feb;40(1):29-31. doi: 10.1093/tropej/40.1.29.
This study reports on the possible role of perinatal and early infantile factors in the aetiology of the 'wheezy baby syndrome'. Over a 2 year period we recruited 150 infants from the outpatients department who had a typical wheezing attack, with chest X-ray showing only hyperinflation and non-specific increased markings, and who had been born in hospital with available perinatal and postnatal records. One hundred and fifty control infants were also recruited. A retrospective study was then undertaken comparing the two groups of infants for the incidence of neonatal problems and the incidence of previous lower respiratory tract infections. The results showed that 40 per cent of cases had previously had meconium aspiration syndrome compared with only 2.6 per cent of controls, and that 26.6 per cent of cases had previously had at least one lower respiratory tract infection compared with 5.3 per cent of controls. Other factors, including the incidence of transient tachypnea, and personal and family history of atopy, showed no significant trends. Meconium aspiration syndrome and lower respiratory tract infections are important aetiological factors in the pathogenesis of 'wheezy baby syndrome', rather than inheritance of atopic diathesis.
本研究报告围产期及婴儿早期因素在“喘息婴儿综合征”病因学中可能发挥的作用。在两年时间里，我们从门诊招募了150名有典型喘息发作的婴儿，其胸部X光仅显示肺过度充气和非特异性纹理增多，且这些婴儿在医院出生，有可用的围产期和产后记录。还招募了150名对照婴儿。随后进行了一项回顾性研究，比较两组婴儿的新生儿问题发生率和既往下呼吸道感染发生率。结果显示，40%的病例既往有胎粪吸入综合征，而对照组仅为2.6%；26.6%的病例既往至少有一次下呼吸道感染，而对照组为5.3%。其他因素，包括短暂性呼吸急促的发生率以及特应性个人和家族史，均未显示出显著趋势。胎粪吸入综合征和下呼吸道感染是“喘息婴儿综合征”发病机制中的重要病因因素，而非特应性素质的遗传。
