5''-氨基-3,5''-二脱氧丁胺卡那霉素A的合成
Synthesis of 5''-amino-3,5''-dideoxybutirosin A.
作者信息
Watanabe I, Tsuchiya T, Nakamura F, Hamada M, Umezawa S
出版信息
J Antibiot (Tokyo). 1978 Sep;31(9):863-7. doi: 10.7164/antibiotics.31.863.
PMID:81829
Abstract
The titled compound was prepared by condensation of 3'-deoxyparomamine derivative (5) with 2,3-O-bis(p-nitrobenzoyl)-5-O-tosyl-D-xylofuranosyl bromide followed by 1-N-acylation with the active ester of (S)-4-benzyloxycarbonylamino-2-hydroxybutyric acid. The compound was slightly more active than 3'-deoxybutirosin A against Pseudomonas.
摘要
将3'-脱氧巴龙胺衍生物（5）与2,3-O-双（对硝基苯甲酰基）-5-O-甲苯磺酰基-D-木糖呋喃糖溴化物缩合，然后用（S）-4-苄氧羰基氨基-2-羟基丁酸的活性酯进行1-N-酰化反应，制备得到标题化合物。该化合物对假单胞菌的活性略高于3'-脱氧丁胺卡那霉素A。
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