Schlaifer D, Dastugue N, Brousset P, Delsol G, Muller C, Rigal-Huguet F, Attal M, Laurent G, Pris J
Department of Hematology, Hôpital de Purpan, Toulouse, France.
Leukemia. 1994 May;8(5):895-6.
We report here two patients with polycythemia vera (PV) who developed secondary non-Hodgkin's lymphoma (NHL). Both cases were high grade B-cell NHL. Cytogenetic analysis of bone marrow and lymph node was performed in each case and showed numerous chromosomal abnormalities. Of interest, chromosomal abnormalities of the PV and of the NHL clones were different, suggesting the possible involvement of two different clones. A 11q23 breakpoint was common between the two cases and the putative role of this breakpoint in the pathogenesis of the NHLs is discussed.
我们在此报告两例真性红细胞增多症（PV）患者继发非霍奇金淋巴瘤（NHL）的病例。两例均为高级别B细胞NHL。对每例患者的骨髓和淋巴结进行了细胞遗传学分析，结果显示存在众多染色体异常。有趣的是，PV克隆和NHL克隆的染色体异常不同，提示可能涉及两个不同的克隆。两例患者均存在11q23断点，本文讨论了该断点在NHL发病机制中的潜在作用。
