Rettig J, Heinemann S H, Wunder F, Lorra C, Parcej D N, Dolly J O, Pongs O
Zentrum für Molekulare Neurobiologie Hamburg, Institut für Neurale Signalverarbeitung, Germany.
Nature. 1994 May 26;369(6478):289-94. doi: 10.1038/369289a0.
Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.
大鼠脑中电压门控Kv1型钾通道的结构和功能多样性因两种不同类型亚基的结合而增强，这两种亚基分别是膜结合的、形成孔道的α亚基和外周β亚基。我们克隆了一种在大鼠神经系统中特异性表达的β亚基（Kvβ1）。在体外表达系统中，Kvβ1与α亚基的结合赋予了非失活的Kv1通道（延迟整流器）快速的A型失活特性。这种效应由Kvβ1氨基末端的失活球结构域介导。
