大鼠脑Kvβ3钾通道亚基的分子与功能特性
Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit.
作者信息
Heinemann S H, Rettig J, Wunder F, Pongs O
机构信息
Max-Planck-Gesellschaft z.Ed.W. c.V. AG Molecular und zelluläre, Biophysik, Jena, Germany.
出版信息
FEBS Lett. 1995 Dec 27;377(3):383-9. doi: 10.1016/0014-5793(95)01377-6.
A novel potassium channel beta-subunit (Kv beta 3) was cloned from rat brain being the third member of a Kv beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to Kv beta 1.1. Kv beta 3 is primarily expressed in rat brain having a distribution distinct to those of Kv beta 1.1 and Kv beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted Kv1.4 but not in other members of the Kv1 channel family. Similarly to Kv beta 1.1, the Kv beta 3-induced inactivation is regulated by the intracellular redox potential.
从大鼠脑中克隆出一种新型钾通道β亚基（Kvβ3），它是Kvβ亚基基因家族的第三个成员。它是一种由403个氨基酸残基组成的蛋白质，与Kvβ1.1的氨基酸序列同源性为68%。Kvβ3主要在大鼠脑中表达，其分布与Kvβ1.1和Kvβ2不同。该亚基还具有较长的N端结构，可诱导N端缺失的Kv1.4失活，但不能诱导Kv1通道家族的其他成员失活。与Kvβ1.1类似，Kvβ3诱导的失活受细胞内氧化还原电位的调节。
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