Zakrevskiĭ V I, Kubatiev A A
Patol Fiziol Eksp Ter. 1994 Jan-Mar(1):19-20.
The negatively charged liposomes of different phospholipid composition were examined for their effects on platelet aggregation induced in vitro by thrombin. Negatively charged dicetylphosphate and phosphatidylinositol failed to affect the aggregation of platelet suspension. The liposomes that contain yolk lecithin-phosphatidylserine-cholesterol (4:4:2) caused a dose-dependent increase in their aggregation. Replacement of yolk lecithin by dipalmitoylphosphatidylcholine eliminated the activating effect of phosphatidylserine. It is suggested that platelet activation is associated with the transfer of phosphatidylserine from liposomes to cells.
研究了不同磷脂组成的带负电荷脂质体对凝血酶体外诱导血小板聚集的影响。带负电荷的磷酸二鲸蜡酯和磷脂酰肌醇不影响血小板悬浮液的聚集。含有蛋黄卵磷脂 - 磷脂酰丝氨酸 - 胆固醇（4:4:2）的脂质体使其聚集呈剂量依赖性增加。用二棕榈酰磷脂酰胆碱替代蛋黄卵磷脂消除了磷脂酰丝氨酸的激活作用。提示血小板活化与磷脂酰丝氨酸从脂质体向细胞的转移有关。
