Zakrevskiĭ V I, Rud'ko I A, Kubatiev A A
Biull Eksp Biol Med. 1992 Nov;114(11):464-6.
The incubation of platelet-rich plasma of rats with liposomes has changed cell functional activity. Lipid composition of liposomes modulated the ability of the platelets to respond to ADP. Vesicles, containing phosphatidylserine, phosphatidylinositol or stearylamine inhibited the aggregation by 70, 30 and 40%, respectively. The inhibition of aggregation by phosphatidylserine-containing liposomes was of linear and dose-dependent character. The maximal inhibition was reported at 10-min incubation of liposomes with platelets. The impairment of platelets aggregation can be explained by interactions of liposomes with plasma coagulation factors and blocking the receptors on the platelets membranes.
将大鼠富含血小板血浆与脂质体孵育会改变细胞功能活性。脂质体的脂质组成调节了血小板对二磷酸腺苷（ADP）的反应能力。含有磷脂酰丝氨酸、磷脂酰肌醇或硬脂胺的囊泡分别使聚集抑制了70%、30%和40%。含磷脂酰丝氨酸脂质体对聚集的抑制呈线性且剂量依赖性。据报道，脂质体与血小板孵育10分钟时抑制作用最大。血小板聚集受损可通过脂质体与血浆凝血因子的相互作用以及阻断血小板膜上的受体来解释。
