Chinchilla M, Guerrero O M, Catarinella G, Reyes L
Departamento de Parasitología, Facultad de Microbiología, Universidad de Costa Rica.
Rev Biol Trop. 1993 Aug;41(2):197-202.
Blood inoculation in mice showed that Toxoplasma organisms circulate in blood after 1 h of oocyst infection. Parasites were detected up to 15 days later and then disappeared from the bloodstream concomitantly with cyst formation in the brain, probably due to antibody presence. Immunosuppression caused by cortisone acetate treatment induced Toxoplasma bloodstream invasion in chronically infected mice and hamsters, causing death in some. Natural dissemination is discussed in relation with congenital toxoplasmosis. Induced immunosuppressive effect is compared with that produced by natural diseases such as Hodgkin, lymphoma, AIDS and others.
对小鼠进行血液接种显示，卵囊感染1小时后，弓形虫病原体便会在血液中循环。在15天内都能检测到寄生虫，之后它们从血液中消失，与此同时大脑中形成囊肿，这可能是由于抗体的存在。醋酸可的松治疗引起的免疫抑制导致慢性感染的小鼠和仓鼠出现弓形虫血液感染，部分小鼠和仓鼠因此死亡。文中讨论了与先天性弓形虫病相关的自然传播情况。将诱导产生的免疫抑制作用与霍奇金病、淋巴瘤、艾滋病等自然疾病所产生的免疫抑制作用进行了比较。
