Brown D R, Davis N L, Lepawsky M, Cunningham J, Kortbeek J
Department of Surgery, University of British Columbia, Vancouver, Canada.
Am J Surg. 1994 May;167(5):485-9. doi: 10.1016/0002-9610(94)90240-2.
To examine the effectiveness of hyperbaric oxygen (HBO) therapy in the treatment of major truncal necrotizing infections, a retrospective (1980 to 1992) analysis of the medical records of 30 patients treated with HBO therapy and 24 patients treated without HBO therapy was undertaken. The two groups were similar; however, there was a selection bias towards more frequent clostridial infections in a younger population in the HBO group. There was no difference in length of hospital stay, intensive care unit (ICU) stay, or duration of antibiotic therapy between groups. The mortality rates were 9/30 (30%) in the HBO group versus 10/24 (42%) (nonsignificant difference) in the non-HBO group. The total number of operations was greater in the HBO-treated group. This study failed to show that the use of HBO in the treatment of major truncal necrotizing infections statistically reduced mortality or the number of débridements. We believe, however, that the apparent selection bias and the trend towards increased survival in the HBO-treated group (12%) justifies the continued use of and research with HBO therapy.
为研究高压氧（HBO）疗法治疗躯干严重坏死性感染的有效性，对30例接受HBO治疗的患者和24例未接受HBO治疗的患者的病历进行了回顾性分析（1980年至1992年）。两组情况相似；然而，HBO组存在选择偏倚，年轻人群中梭菌感染更为常见。两组之间的住院时间、重症监护病房（ICU）住院时间或抗生素治疗持续时间无差异。HBO组的死亡率为9/30（30%），非HBO组为10/24（42%）（无显著差异）。HBO治疗组的手术总数更多。本研究未能表明使用HBO治疗躯干严重坏死性感染在统计学上能降低死亡率或清创次数。然而，我们认为，明显的选择偏倚以及HBO治疗组生存率提高的趋势（12%）证明继续使用HBO疗法并进行相关研究是合理的。
