Kusumi A, Kumagai K
Dept. of Microbiology, Tohoku University School of Dentistry.
Gan To Kagaku Ryoho. 1994 May;21(6):915-25.
Interleukin 3 (IL-3) was initially described in the supernates of cultures of viral-infected murine spleen cells, as a cytokine produced by T lymphocytes can promote differentiation of immature T lymphocytes. Later, it was found that IL-3 exhibited a striking effect on hematopoiesis. The recombinant molecule of murine and human IL-3 can promote the sustained proliferation of clones of mast cells and basophils. It also acts as a colony stimulating factor (CSF) for bone marrow cells. Although other CSFs generally stimulate specific lineages of myeloid or erythroid cells, IL-3 stimulates bone marrow to induce proliferation of a variety of clonal cell populations, including colonies of granulocytes, macrophages, megakaryocytes, eosinophils, basophils, mast cells, normoblasts and erythroblasts. Thus, IL-3 is responsible for promoting proliferation of earlier lineage pluripotent stem cells, of hematopoietic cells and lymphoid cells. Recently, it is also suggested, as to its effects on lymphocytes, that IL-3 may possibly be a factor responsible for T lymphocytes to be differentiating extra-thymically.
白细胞介素3（IL-3）最初是在病毒感染的小鼠脾细胞培养上清液中被描述的，作为一种由T淋巴细胞产生的细胞因子，它可以促进未成熟T淋巴细胞的分化。后来发现，IL-3对造血作用有显著影响。小鼠和人IL-3的重组分子可促进肥大细胞和嗜碱性粒细胞克隆的持续增殖。它还作为骨髓细胞的集落刺激因子（CSF）。尽管其他CSF通常刺激髓系或红系细胞的特定谱系，但IL-3刺激骨髓诱导多种克隆细胞群体增殖，包括粒细胞、巨噬细胞、巨核细胞、嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞、正成红细胞和早幼红细胞集落。因此，IL-3负责促进早期谱系多能干细胞、造血细胞和淋巴细胞的增殖。最近，关于其对淋巴细胞的作用也有人提出，IL-3可能是T淋巴细胞在胸腺外分化的一个相关因子。
