Arock Michel, Schneider Elke, Boissan Mathieu, Tricottet Viviane, Dy Michel
Department of Cellular and Molecular Hematology, UPRES-EA 2509, Faculty of Pharmacy, Paris, France.
J Leukoc Biol. 2002 Apr;71(4):557-64.
Basophils are rare, circulating leukocytes derived from hematopoietic CD34+ progenitors. The identification of cytokines promoting their development in vitro has led to substantial advances in understanding their differentiation process. An important role could be assigned to interleukin-3 (IL-3), which supports the maturation of hematopoietic progenitors into basophils in vitro and in vivo. In contrast to other myeloid lineages, a specific basophil growth factor has not yet been discovered. Furthermore, it is still unclear whether basophils possess a lineage-restricted progenitor or whether they share a common ancestor with mast cells (MC), eosinophils, or even megakaryocytes. Partial answers to these questions could be provided using in vitro culture systems or taking advantage of hematological disorders, such as chronic and acute myeloid leukemia (CML and AML), some myelodysplastic syndromes, and the very rare acute basophilic leukemia in which basophilic differentiation occurs.
嗜碱性粒细胞是一种罕见的循环白细胞，来源于造血CD34+祖细胞。在体外促进其发育的细胞因子的鉴定，在理解其分化过程方面取得了重大进展。白细胞介素-3（IL-3）可能起着重要作用，它在体外和体内都能支持造血祖细胞成熟为嗜碱性粒细胞。与其他髓系谱系不同，尚未发现特定的嗜碱性粒细胞生长因子。此外，嗜碱性粒细胞是否拥有谱系受限的祖细胞，或者它们是否与肥大细胞（MC）、嗜酸性粒细胞甚至巨核细胞有共同的祖先，目前仍不清楚。使用体外培养系统或利用血液系统疾病，如慢性和急性髓系白血病（CML和AML）、一些骨髓增生异常综合征以及发生嗜碱性分化的非常罕见的急性嗜碱性粒细胞白血病，可能会为这些问题提供部分答案。
