Crăiţoiu M, Preoteasa D
Facultatea de Stomatologie Craiova.
Oftalmologia. 1994 Apr-Jun;38(2):135-7, 140.
The observation of an 11-years-old child is presented. He had bilateral congenital palpebral ptosis and multiple facial malformations, like maxillary and mandibular hypoplasia, dental malpositions, ogival palace, anomalies of the external ear, lesions determined by a latero-facial dechyscence (perforation 6, 7, 8). The affection was produced by a embryogenesis disturbance following the existence of two pathological genes. Their actions were overlapped during the 7--8 and 11 weeks of embryonic life, which caused damages in the maxillary and mandibular bones suture, which allow the formation of the inferior and middle stage of the face.
报告了一名11岁儿童的观察情况。他患有双侧先天性睑下垂和多种面部畸形，如下颌骨和上颌骨发育不全、牙齿错位、尖顶腭、外耳畸形、面侧裂（6、7、8号穿孔）所致病变。这种疾病是由两个病理基因存在后胚胎发育紊乱引起的。它们的作用在胚胎生命的第7至8周和第11周重叠，导致上颌骨和下颌骨缝合处受损，而此处是面部中下段形成的部位。
