Boehm K D, Yun J K, Garner C, Strohl K P, Elmets C A
Department of Dermatology, Case Western Reserve University, Cleveland, OH.
Lymphokine Cytokine Res. 1994 Feb;13(1):9-13.
Human sweat and eccrine sweat glands contained the multifunctional polypeptide cytokines, interleukin-1 alpha and beta (IL-1 alpha and beta). To determine whether the sweat gland itself is an actual site of transcription for cytokines we performed in situ hybridization on histologic sections of normal human skin. In this report we show that the mRNAs encoding the cytokines IL-1 alpha, IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha) are present in normal human skin eccrine sweat gland duct and secretory coil epithelium. These results suggest that in vivo the sweat gland is a production site for cytokine polypeptides and may contribute to the exceedingly large quantities of these cytokine proteins found in the epidermis.
人类汗液和外泌汗腺含有多功能多肽细胞因子，白细胞介素-1α和β（IL-1α和β）。为了确定汗腺本身是否是细胞因子的实际转录位点，我们对正常人皮肤的组织学切片进行了原位杂交。在本报告中，我们表明，编码细胞因子IL-1α、IL-1β和肿瘤坏死因子-α（TNF-α）的mRNA存在于正常人皮肤外泌汗腺导管和分泌盘曲上皮中。这些结果表明，在体内汗腺是细胞因子多肽的产生部位，可能是表皮中发现的这些细胞因子蛋白大量存在的原因。
