Miura H, Nagata K, Hirata Y, Satoh Y, Watahiki Y, Hatazawa J
Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan.
J Neuroimaging. 1994 Apr;4(2):91-6. doi: 10.1111/jon19944291.
To elucidate the evolution of crossed cerebellar diaschisis, cerebral oxygen metabolism was measured repeatedly by positron emission tomography (PET) in 35 consecutive patients with unilateral cerebral infarction within the territory of middle cerebral artery. The crossed cerebellar diaschisis was defined as significant when the laterality ratio of cerebral oxygen metabolism between the left and right cerebellar hemispheres exceeded the control range (mean +/- 2 standard deviations) as derived from 27 age-matched normal volunteers. Significant crossed cerebellar diaschisis was observed in 31 patients (89%) on the initial PET studies. Of these 31 patients, 23 with infarcts involving the frontal sensorimotor cortex persistently had crossed cerebellar diaschisis up to 5 years after onset, whereas the diaschisis disappeared in 8 patients with smaller infarcts mainly in the frontal or parietal lobe without recovery of oxygen metabolism in the infarcted areas. These present results suggest that crossed cerebellar diaschisis can exist persistently even in the late stage in those having a lesion involving the cortical pontine-cerebellar pathways.
为了阐明交叉性小脑失联络的演变过程，我们通过正电子发射断层扫描（PET）对35例连续的大脑中动脉供血区内单侧脑梗死患者的脑氧代谢进行了反复测量。当左右小脑半球之间的脑氧代谢偏侧比超过27名年龄匹配的正常志愿者得出的对照范围（均值±2个标准差）时，交叉性小脑失联络被定义为显著。在最初的PET研究中，31例患者（89%）观察到显著的交叉性小脑失联络。在这31例患者中，23例梗死累及额叶感觉运动皮层的患者在发病后长达5年持续存在交叉性小脑失联络，而8例梗死较小主要位于额叶或顶叶的患者失联络消失，梗死区域的氧代谢未恢复。这些目前的结果表明，即使在病变累及皮质脑桥小脑通路的患者晚期，交叉性小脑失联络也可能持续存在。
