佐治亚州马斯考吉县的结核病研究。卡介苗接种社区试验的二十年评估。
Tuberculosis studies in Muscogee County, Georgia. Twenty-year evaluation of a community trial of BCG vaccination.
作者信息
Comstock G W, Woolpert S F, Livesay V T
出版信息
Public Health Rep. 1976 May-Jun;91(3):276-80.
Abstract
A controlled trial of BCG vaccination was conducted in 1950 in Muscogee County, Ga., and Russell County, Ala. The study population consisted of 64,136 volunteers over the age of 5 years who had satisfactory skin tests with 5 tuberculin units of purified protein derivative and whose chest photofluorograms were considered by two readers to show no significant pulmonary abnormalities. Approximately half of the nonreactors to tuberculin were vaccinated with the Tice strain of BCG by a multiple-puncture method. During a 20-year period of follow-up, 207 cases of tuberculosis were identified among the persons who had been tuberculin reactors in 1950, 36 cases were identified among the controls, and 32 cases were identified among the vaccinees. The average annual case rates per 100,000 were 47.0 for reactors, 13.4 for controls, and 12.6 for vaccinees.
摘要
1950年在佐治亚州马斯考吉县和阿拉巴马州拉塞尔县进行了一项卡介苗接种对照试验。研究人群包括64136名5岁以上的志愿者，他们对5个结核菌素单位的纯化蛋白衍生物皮肤试验结果良好，且两名阅片者认为其胸部荧光照片显示无明显肺部异常。大约一半对结核菌素无反应者通过多点穿刺法接种了卡介苗蒂西株。在20年的随访期内，1950年结核菌素反应者中发现了207例结核病病例，对照组中发现了36例，接种疫苗者中发现了32例。每10万人的年均发病率，反应者为47.0，对照组为13.4，接种疫苗者为12.6。
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