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生物系统中示踪剂动力学的广义理论。

Generalized theory of the kinetics of tracers in biological systems.

作者信息

Gitterman M, Weiss G H

机构信息

Physical Sciences Laboratory, National Institutes of Health, Bethesda, MD 20892.

出版信息

Bull Math Biol. 1994 Mar;56(2):171-86. doi: 10.1007/BF02460638.

Abstract

Most theoretical analyses of tracer kinetics in capillaries contain an implicit assumption that the tissues to which they are connected have homogeneous material properties. The microscopic description of the exchange of tracer molecules and tissues is then modeled in terms of first-order kinetics. We consider a class of more general models allowing us to assess the robustness of simplifying assumptions made above. It is shown that when amorphous properties are important the kinetics of the system may differ considerably from those predicted by standard theories.

摘要

大多数关于毛细血管中示踪剂动力学的理论分析都隐含着一个假设,即与它们相连的组织具有均匀的物质属性。然后,根据一级动力学对示踪剂分子与组织间的交换进行微观描述。我们考虑一类更通用的模型,以便评估上述简化假设的稳健性。结果表明,当非晶态属性很重要时,系统的动力学可能与标准理论预测的动力学有很大差异。

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