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生理转运时间分布的时刻以及药物在体内处置的时间进程。

Moments of physiological transit time distributions and the time course of drug disposition in the body.

作者信息

Weiss M

出版信息

J Math Biol. 1982;15(3):305-18. doi: 10.1007/BF00275690.

DOI:10.1007/BF00275690
PMID:7153675
Abstract

Characterizing the tissue distribution kinetics of drugs by physiological and physico-chemical parameters and using a circulatory model the time course of blood concentration after intravenous injection is predicted for linear pharmacokinetic systems. The interrelationships between the first three (zero to second) moments of the distribution functions of organ transfer times, circulation times and residence times of drug molecules in the body are described. Utilizing literature data the model is applied to the analysis of lidocain kinetics in humans.

摘要

通过生理和物理化学参数表征药物的组织分布动力学，并使用循环模型预测线性药代动力学系统静脉注射后血药浓度的时间进程。描述了药物分子在体内器官转运时间、循环时间和停留时间分布函数的前三个（零至二阶）矩之间的相互关系。利用文献数据，将该模型应用于人体利多卡因动力学分析。

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1
Moments of physiological transit time distributions and the time course of drug disposition in the body.生理转运时间分布的时刻以及药物在体内处置的时间进程。
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5
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Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. I. Log-convex drug disposition curves.利用某些类停留时间分布的性质进行线性药代动力学的归纳。I. 对数凸性药物处置曲线。
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本文引用的文献

1
Applications of a recirculatory stochastic pharmacokinetic model: limitations of compartmental models.循环随机药代动力学模型的应用：房室模型的局限性
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Tissue distribution kinetics of tetraethylammonium ion in the rat.大鼠体内四乙铵离子的组织分布动力学
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Generalized theory of the kinetics of tracers in biological systems.生物系统中示踪剂动力学的广义理论。
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Kinetic analysis of the drug permeation process across the intestinal epithelium.药物跨肠上皮渗透过程的动力学分析。
Pharm Res. 1994 Nov;11(11):1646-51. doi: 10.1023/a:1018926324682.
7
Hemodynamic influences upon the variance of disposition residence time distribution of drugs.血流动力学对药物处置停留时间分布方差的影响。
J Pharmacokinet Biopharm. 1983 Feb;11(1):63-75. doi: 10.1007/BF01061768.
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Modelling of initial distribution of drugs following intravenous bolus injection.
Eur J Clin Pharmacol. 1983;24(1):121-6. doi: 10.1007/BF00613938.
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Use of gamma distributed residence times in pharmacokinetics.伽马分布的驻留时间在药代动力学中的应用。
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The variance of the distribution of traversal times in a capillary bed.
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6
Pharmacokinetic aspects of intravenous regional anesthesia.静脉区域麻醉的药代动力学方面
Anesthesiology. 1971 Jun;34(6):538-49. doi: 10.1097/00000542-197106000-00014.
7
Pharmacokinetics of lidocaine in man.利多卡因在人体中的药代动力学。
Clin Pharmacol Ther. 1971 Jan-Feb;12(1):105-16. doi: 10.1002/cpt1971121105.
8
Stimulus-response method for flows and volumes in slightly perturbed constant parameter systems.微扰常参数系统中流量和体积的刺激-响应方法
Bull Math Biophys. 1971 Jun;33(2):225-33. doi: 10.1007/BF02579475.
9
Transfer times across the human body.
Bull Math Biophys. 1972 Mar;34(1):33-44. doi: 10.1007/BF02477022.
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Stochastic models for tracer experiments in the circulation. 3. The lumped catenary system.循环中示踪剂实验的随机模型。3. 集总链状系统。
J Theor Biol. 1971 Dec;33(3):491-515. doi: 10.1016/0022-5193(71)90093-2.